Proteins that prevent the cancerous transformation of cells are referred to as tumor suppressors. The transcription factor p53 is one of the most relevant and best described tumor suppressors. A collaborative study of the group of Michael Schupp with the Medical University Graz (Ass.-Prof. Andreas Prokesch) and the German Institute of Human Nutrition in Postdam-Rehbrücke (Prof. Tim Schulz) describes the unexpected observation that p53 protein accumulates in the liver of starved mice. This accumulation of p53 protein was mediated by a cellular energy sensor and required for the starvation-associated metabolic adaption. These findings may be used to develop new therapeutic strategies for metabolic or oncologic diseases.
Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis. Prokesch A, Graef FA, Madl T, Kahlhofer J, Heidenreich S, Schumann A, Moyschewitz E, Pristoynik P, Blaschitz A, Knauer M, Muenzner M, Bogner-Strauss JG, Dohr G, Schulz TJ, Schupp M. FASEB J. 2016 Nov 3. [Epub ahead of print]
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